解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:NKp46 expression in natural killer (NK) cells has recently been shown to affect the responsiveness to antiviral treatment in hepatitis C virus (HCV)-infected patients. However, the density of NKp46 on intrahepatic NK cells is remarkably higher than that on peripherally circulating NK cells, whereas the bioph...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001031
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Two apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African American (AA) recipient race are associated with worse allograft survival in deceased-donor kidney transplantation (DDKT) from AA donors. To detect other factors impacting allograft survival from deceased AA kidney donors, APOL1 ren...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000969
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of organ grafts has been delineated as a genuine factor contributing to reperfusion injury and graft dysfunction after transplantation. METHODS:In a first clinical series of 6 patients, cold-stored livers, all allocated by the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000915
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Early outcomes after human immunodeficiency virus (HIV) + liver transplantation (LT) are encouraging, but data are lacking regarding long-term outcomes and comparisons with matched HIV- patients. METHODS:We examined outcomes among 180 HIV+ LT, and compared outcomes to matched HIV- counterfactuals (Scientifi...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000829
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:The use of liver allografts from elderly donors (≥70 years) has increased because of organ shortage and increased life expectancy. The aim of this study is to evaluate the current utilization of elderly donors in United States, recipient selection, and their posttransplant outcomes. METHODS:A linkage betw...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000806
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Given growth in kidney transplant waitlists and discard rates, donor kidney acceptance is an important problem. We used network analysis to examine whether organ procurement organization (OPO) network centrality affects discard and outcomes. METHODS:We identified 106,160 deceased donor kidneys recovered for...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000773
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:HLA-G is a nonclassical MHC class I molecule and its physiological expression restricted to placental extravillous trophoblasts contributes to maternal tolerance to the semiallogeneic fetus. Aberrant expression of HLA-G in human organ grafts has been proposed to contribute to graft acceptance. METHODS:We st...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000761
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Renal ischemia-reperfusion (I/R) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute renal dysfunction. Recent studies have revealed that deletion of Gα12 mitigates the renal damage due to I/R injury. Our previous study showed that activation of dopamine D3 receptor (D3R) incre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000762
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Current desensitization (DES) methods are not always effective. Thus, novel, more effective approaches are desirable. Interleukin (IL)-6 is an attractive target as it promotes B-cell differentiation to plasma cells, is important for immunoglobulin production, and induces Th17 cells. Here, we undertook a phas...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000741
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Dysregulation of the coagulation system due to inflammatory responses and cross-species molecular incompatibilities represents a major obstacle to successful xenotransplantation. We hypothesized that complement inhibition mediated by transgenic expression of human CD46 in pigs might also regulate the coagula...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000746
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) reinfection of the liver allograft after transplantation is universal, with some individuals suffering severe disease recurrence. Predictive markers of recurrent disease severity are urgently needed. In this study, we used a cluster of differentiation (CD) microarray to predict the se...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000617
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Significant disparity exists in the United Kingdom between the need for organ transplant and supply of deceased donor organs. In the recent years, efforts to increase donation has improved the rate of mainly deceased donors after circulatory death and from older donors. The rate of donation from pediatric po...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000575
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Kidney transplant graft survival is almost uniformly superior for initial transplants compared to repeat transplants. We investigate the association between first second kidney transplant graft survival in patients who underwent initial transplant during their pediatric years whether age at se...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000686
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:It is unclear if the category of acute rejection with intimal arteritis (ARV) is relevant to short- and long-term clinical outcomes and if the graft outcomes are affected by the severity of intimal arteritis. METHODS:One hundred forty-eight ARV episodes were reviewed and categorized according to the 2013 Ba...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000640
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:In response to recent studies, a better understanding of the risks of renal complications among African American and biologically related living kidney donors is needed. METHODS:We examined a database linking U.S. registry identifiers for living kidney donors (1987-2007) to billing claims from a private hea...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000733
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000493
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:We have previously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts generates a tryptophan-deficient environment that selectively inhibits proliferation and induces apoptosis of bystander CD4+ and CD8+ T cells, but not pancreatic islets. Because these immune cell...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000661
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Gastrointestinal complications are common in patients after lung and heart transplantation. Endoscopy is a standard method for the assessment of gastrointestinal morbidities. The aim of this study was to analyze the number and type of complications during endoscopic procedures in patients before and after lu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000517
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Despite proven efficacy of prolonged cytomegalovirus (CMV) prophylaxis using valganciclovir 900 mg/day, some centers use 450 mg/day due to reported success and cost savings. This multicenter, retrospective study compared the efficacy and safety of 6 months of low-dose versus high-dose valganciclovir prophyla...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000000570
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Liver transplantation is a widely accepted treatment for end-stage liver disease. The aim of our study was to investigate the imbalance between T helper type 17 (Th17) and CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells during hepatic allograft rejection in a rodent grafts model because their roles in live...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000666
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The impact of nutritional status on outcome of allogeneic stem cell transplantation (alloSCT) is controversial. This study investigates the influence of pretransplant weight loss and serologic indicators of nutritional homeostasis on relapse and death of acute myeloid leukemia (AML) after alloSCT. METHODS:P...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000471
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Patient-level risk factors for delayed graft function (DGF) have been well described. However, the Organ Procurement and Transplantation Network definition of DGF is based on dialysis in the first week, which is subject to center-level practice patterns. It remains unclear if there are center-level differenc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000450
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Arterial hypertension (HT) is common in renal transplant recipients (RTRs). Control of HT is not optimal in this high-risk population despite recommendations for target blood pressure levels under 130/80 mm Hg. METHODS:We performed a cross-sectional analysis of the prevalence of uncontrolled HT, and using a...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000467
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Graft arterial disease (GAD) is a major cause of late graft loss after organ transplantation. Alloimmune responses and vascular remodeling eventually cause the transplant organ to develop GAD. In this study, we aimed to limit the development of GAD by inhibiting alloimmune responses and vascular smooth muscl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000576
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Lung transplant recipients are among those with the highest risk of influenza infection and complications each year. A few studies show adequate responses after influenza immunization; no studies examined the season-long protection. METHODS:Influenza antibody concentrations were measured using hemagglutinat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000391
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:In nontransplant patients with chronic hepatitis C virus (HCV), HCV genotype has been linked with a differential response to antiviral therapy, risk of steatosis and fibrosis, as well as all-cause mortality, but the role of HCV genotypes in posttransplant disease progression is less clear. METHODS:Using the...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000000413
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Circulation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide dendritic cells and T cells to lymphatics and then to draining lymph nodes (dLN). Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 (V...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000561
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:We sought to determine the risk factors, molecular epidemiology, antibiotic therapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa in solid organ transplant (SOT) recipients. METHODS:All episodes of bacteremia occurring in SOT recipients were prospectively doc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000366
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Increasing use of kidney grafts for simultaneous liver and kidney (SLK) transplants is causing concern about the most effective utilization of scarce kidney graft resources. This study evaluated the impact of implementing the proposed United Network for Organ Sharing SLK transplant policy on outcomes for end...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000270
更新日期:2015-02-01 00:00:00
abstract::The United Network for Organ Sharing is poised to resolve geographic disparity in liver transplantation and promote allocation based on medical urgency. At the time of writing, United Network for Organ Sharing is considering redistricting the organ procurement and transplantation network so that patient model for end-...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000000656
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Hyperparathyroidism is reported in 10% to 66% of renal transplant recipients (RTR). The influence of persisting hyperparathyroidism on long-term clinical outcomes in RTR has not been examined in a large prospective study. METHODS:We investigated the association between baseline parathyroid hormone (PTH) lev...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000583
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The impact of recipient body mass index on graft and patient survival after pancreas transplantation is not well known. METHODS:We have analyzed data from all pancreas transplant recipients reported in the Scientific Registry of Transplant Recipients between 1987 and 2011. Recipients were categorized into B...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000226
更新日期:2015-01-01 00:00:00
abstract::Prospective clinical trials are constructed with high levels of internal validity. Sample size and power considerations usually address primary endpoints. Primary endpoints have traditionally included events that are becoming increasingly less common and thus have led to growing use of composite endpoints and noninfer...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000000581
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Patients with pretransplantation strong donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) are at higher risk for rejection. We aimed to study the safety of kidney transplantation in patients with lower strength DSAs in a prospective cohort study. METHODS:Three hundred and seventy-three cons...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000191
更新日期:2014-11-27 00:00:00
abstract:BACKGROUND:Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS:We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 pat...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000000160
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:Optical coherence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procured by laparoscopic procedures were very swollen in response to the brief period of ischemia experienced between the time of arterial vessel clamping and flushing the excised kidney w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000154
更新日期:2014-10-27 00:00:00
abstract::Diarrhea is a frequent but overlooked complication of kidney transplantation. Diarrhea is repeatedly neglected, often considered by patients and clinicians an unavoidable side effect of immunosuppressive regimens. It is, however, associated with a significant impairment in life quality. Severe and chronic posttranspla...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000000335
更新日期:2014-10-27 00:00:00
abstract:BACKGROUND:Diagnosing acute rejection (AR) in kidney transplant recipients typically requires an invasive kidney biopsy. A previous study has suggested that expression of five genes in peripheral blood can indicate the presence of AR in American pediatric kidney transplant recipients. This study aims to validate if the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000138
更新日期:2014-10-15 00:00:00
abstract:BACKGROUND:Geographic variation in kidney transplantation rates in the United States has been described previously but remains unexplained by age, race, sex, or socioeconomic status differences. Geographic variations in the concentration of poverty appear to impact end-stage renal disease care and potentially access to...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000125
更新日期:2014-09-27 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen species. We evaluate...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000305
更新日期:2014-09-27 00:00:00